CEM微波合成用于Aspartimide的研究

更新時(shí)間：2012-06-29 點(diǎn)擊次數(shù)：2038

INTRODUCTION

VIP （vasoactive intestinal peptide）, a peptide hormone, has been implicated in a number of biological processes including: increasing digestive system motility, stimulating pepsinogen secretion, controlling the mammalian circadian timekeeping machinery, regulating prolactin secretion, and causing vasodilation. One problem with synthesis of VIP is aspartimide formation during Fmoc deprotection. Aspartimide formation occurs most frequently in peptides containing Asp followed by Asn（Trt）, Gly, Thr, or Ser. The use of 5% piperazine with 0.1 M HOBt for the deprotection solution can readily reduce the amount of aspartimide formation during microwave peptide synthesis providing the VIP peptide in high crude purity compared to the conventional method.

Figure 1: Aspartimide Formation

Liberty 全自動(dòng)流動(dòng)微波多肽合成系統(tǒng)

更多詳情，請培安公司：
：北京：上海：成都：廣州：
: [email protected] ：www.pynnco.com

上一篇：CEM微波合成用于Racemization的研究
下一篇：Fast Trac快速脂肪分析儀